I am currently running 4 nodes, @ 1.2.2.

I was curious if it mattered what node I have my clients connect to. Using the python cql driver :
https://pypi.python.org/pypi/cql/

It doesn't give me the option to specify multiple client addresses, just one. Will this be an issue?

My assumption is that given that the data is spread out across the ring, it shouldn't really matter since chances are it will need to pull data from another node anyway.