It will have a performance penalty, so it would be better to spread the compactions over a period of time. But Cassandra will still take care of any reads/writes (within the given timeout).

2012/2/3 myreasoner <>
If every node in the cluster is running major compaction, would it be able to
answer any read request?  And is it wise to write anything to a cluster
while it's doing major compaction?

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